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Chemotherapy was potentiated by E7449 and one agent had sizeable antitumor activity in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer mobile lines, very likely through TNKS inhibition. According to this chance, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization and substantial